Synthesis, computational study, solvatochromism and biological studies of thiazole-owing hydrazone derivatives
نویسندگان
چکیده
In the present work, we have synthesized thiazole-hydrazone conjugates 5(a–h) and characterized them using various analytical techniques such as UV, IR, NMR, mass spectrometry. Solvatochromic properties were evaluated in ten solvents with different polarity quantum chemical parameters a DFT study. The antibacterial activity results revealed that compounds 5c, 5d 5g exhibited good efficacy remaining displayed significant activity. screened for their cytotoxic against HepG2 MCF-7 cell lines, all potency towards cancer lines. anti-inflammatory of thiazole derivatives was determined MMP-2 MMP-9, some showed Furthermore, silico molecular docking performed COX-2 receptor.
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ژورنال
عنوان ژورنال: Chimica techno acta
سال: 2023
ISSN: ['2411-1414', '2409-5613']
DOI: https://doi.org/10.15826/chimtech.2023.10.1.10